Paris St-Germain will be without their entire first-choice strike force of Neymar, Edinson Cavani and Kylian Mbappe when they host Real Madrid.
Neymar is suspended after insulting match officials last season, while Cavani and Mbappe are both injured.
Former Stoke forward Eric Choupo-Moting could start, with doubts over the match fitness of loan signing Mauro Icardi.
Real Madrid also have a number of absentees, with Marcelo the latest player to be ruled out after suffering a neck injury against Levante in La Liga on Saturday.
Luka Modric, Isco and Marco Asensio are also injured, while Nacho and Sergio Ramos are suspended.